The successful scale-up of biotechnological processes from laboratory to industrial scale is crucial for translating innovation to practice. Scale-down simulators have emerged as indispensable tools in this endeavor, enabling the evaluation of potential hosts' adaptability to the dynamic conditions encountered in large-scale fermenters. By simulating these real-world scenarios, scale-down simulators facilitate more accurate estimations of host productivity, thereby improving the process of selecting optimal strains for industrial production. Conventional scale-down systems for detailed intracellular analysis necessitate an elaborate setup comprising interconnected lab-scale reactors such as stirred tank reactors (STRs) and plug-flow reactors (PFRs), often proving time-consuming and resource-intensive. This work introduces a miniaturized bubble column reactor setup (60 mL working volume), enabling individual and parallel carbon-limited chemostat fermentations, offering a more efficient and streamlined approach. The industrially relevant organism