Design, synthesis, molecular docking and anticancer activity of benzothiazolecarbohydrazide-sulfonate conjugates: insights into ROS-induced DNA damage and tubulin polymerization inhibition.

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Tác giả: Ahmed H Afifi, Najla A Altwaijry, Hanaa S Mohamed, Marwa M Mounier, Mohamed A Omar, Aladdin M Srour

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : RSC advances , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 673923

 A series of novel benzothiazolecarbohydrazide-sulfonate conjugates 6a-l were designed, synthesized, and then assessed as potential antiproliferative agents in three distinct human cancer cell lines: MCF-7 (breast cancer), HCT-116 (colon cancer), and PC3 (prostate cancer), along with a normal cell line (BJ-1). The reference standard used was 5-fluorouracil. The results obtained reveal that the newly synthesized analogs demonstrate varying degrees of cytotoxicity against the targeted cell lines
  however, compounds 6i and 6e exhibited the highest efficacy against MCF-7, HCT-116, and PC3 cells with IC
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