Coffee consumption is associated with later age-at-onset of Parkinson's disease.

• Tác giả: Ziv Gan-Or, Dariia Kuzovenkova, Lang Liu, Konstantin Senkevich
• Ngôn ngữ: eng
• Ký hiệu phân loại: 203 Public worship and other practices [formerly 291.3]
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 673960

Tóm tắt

 Observation studies suggest that coffee consumption may lower the risk of Parkinson's disease (PD). The aim of this study was to explore the causal relationship and genetic association between coffee consumption and the age-at-onset (AAO), risk, and progression of PD. Using Mendelian randomization, we identified a significant association between coffee consumption and delayed PD AAO (IVW: OR, 1.91
  95% CI 1.53-2.38
  P=8.072e-09), but no causal association or genetic correlation with PD risk or progression. Our findings suggest a potential protective causal effect of higher coffee consumption on PD AAO, with no evidence of an association with PD risk or progression.