Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment.

• Tác giả: Dumnoensun Pruksakorn, Rungnapha Saeeng, Patamawadee Silalai, Pimpisa Teeyakasem
• Ngôn ngữ: eng
• Ký hiệu phân loại: 364.04 Special topics of criminology
• Thông tin xuất bản: United States : ACS bio & med chem Au , 2025
• Bộ sưu tập: NCBI
• ID: 674077

Tóm tắt

Mycophenolic acid (MPA), a natural compound, was modified to new MPA analogues via the classical method of silylation and esterification. Their cytotoxicity was evaluated in vitro on four osteosarcoma cancer cell lines (MNNG/HOS, U2OS, 143B, and SaOS-2) and human normal cells (hFOB 1.19). The most potent silicon-containing compound