Synthesis and Modification of Cordycepin-Phosphoramidate ProTide Derivatives for Antiviral Activity and Metabolic Stability.

• Tác giả: Marie Hoarau, Suradej Hongeng, Peera Jaru-Ampornpan, Thitiphong Khamkhenshorngphanuch, Suwimon Manopwisedjaroen, Jaraspim Narkpuk, Suppachoke Onnome, Bunpote Siridechadilok, Kitlada Srichomthong, Nitipol Srimongkolpithak, Chanya Srisaowakarn, Amporn Suphatrakul, Sewan Theeramunkong, Ratthiya Thiabma, Aticha Thiraporn, Arunee Thitithanyanont, Thanat Tiyasakulchai
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.13236 Aerospace engineering
• Thông tin xuất bản: United States : ACS bio & med chem Au , 2025
• Bộ sưu tập: NCBI
• ID: 674093

Tóm tắt

In our study, Prodrug nucleoTide (ProTide) technology was applied to cordycepin to enhance its antiviral activities and metabolic stability. Using cordycepin as starting material, we developed a synthetic method to access a series of stereospecific-phosphoramidate derivatives with various ester groups. We also successfully synthesized halogenated cordycepin derivatives via stannylation. Our 17 ProTide-cordycepin derivatives were pharmacologically evaluated for their antiviral activities. Phosphorus diastereomers