Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions.

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Tác giả: Deborah Langrill Beaudoin, Jeremy Matthew Bohl, Abdul Rhman Hassan, Tomomi Ichinose, Megi Kola, Zachary J Sharpe, Angela Shehu

Ngôn ngữ: eng

Ký hiệu phân loại: 004.33 Real-time processing

Thông tin xuất bản: Switzerland : Frontiers in cellular neuroscience , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 674124

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The pupillary light reflex (PLR) is crucial for protecting the retina from excess light. The intrinsically photosensitive retinal ganglion cells (ipRGCs) in the retina are neurons that are critical to generating the PLR, receiving rod/cone photoreceptor signals and directly sensing light through melanopsin. Previous studies have investigated the roles of photoreceptors and ipRGCs in PLR using genetically-modified mouse models. Herein, we acutely ablated photoreceptors using N-nitroso-N-methylurea (MNU) to examine the roles of ipRGCs in the PLR. We conducted PLR and multiple electrode array (MEA) recordings evoked by three levels of light stimuli before and 5 days after MNU intraperitoneal (i.p..) injection using C57BL6/J wildtype (WT) mice. We also conducted these measurements using the rod & cone dysfunctional mice (Gnat1

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