OBJECTIVE: This study aimed to assess the knowledge and attitude of Jordanian radiographers toward Cardiopulmonary Resuscitation (CPR), in addition to exploring factors associated with their knowledge and attitude. METHODS: This was a cross-sectional study. Convenience sampling was used to collect data from 359 radiographers currently working at governmental, university, military, and private hospitals across the country. Data were collected using an online Google form questionnaire between October 5, 2023 and December 27, 2023. The questionnaire included questions about demographic information, knowledge of CPR, and attitude toward performing CPR. The data were analyzed using SPSS IBM software v. 28, and RESULTS: A total of 359 radiographers with a mean age of 31.71±8.22 years participated in the study. More than half of the sample were male (198, 55.2%) compared to 161 (44.8%) females. The mean scores for knowledge of CPR and attitude toward CPR were 5.74 ± 2.31 out of 10 and 3.94 ± 0.46 out of 5, respectively. Radiographers who received CPR training demonstrated significantly higher mean knowledge scores compared to those who did not receive CPR training (M=6.51±2.14, vs M=4.73±2.14, CONCLUSION: Radiographers had poor knowledge of CPR. However, there was a positive attitude toward CPR. Previous CPR training and educational level were significantly associated with higher knowledge and positive attitudes toward CPR, whereas radiographers' age and work experience were significantly associated with higher knowledge. Therefore, continuous CPR training is recommended to increase radiographers' knowledge of CPR.