OBJECTIVE: This study aimed to investigate the effect of empowerment-based interventions on self-efficacy and self-care capacity among adults with sickle cell disease (SCD). METHODS: A randomized control trial was conducted [NCT06296654]. A total of 76 patients were recruited by using a cluster sampling technique in the two health centers in Bahrain from February to May 2022 and randomly allocated to the intervention group ( RESULTS: A total of 68 patients completed the study (36 patients in the intervention group and 32 patients in the control group). After the intervention, the score of SCSES in the intervention group was 37.0 (35.0, 39.8) higher than the control group 28.0 (25.2, 32.0) ( CONCLUSION: Adopting the empowerment-based intervention using the 5As model effectively improves self-efficacy and self-care capacity among patients with SCD.