Pulmonary hypertension (PH) can significantly impact the prognosis of interstitial lung disease (ILD). There are limited studies on the clinical characteristics and risk factors of PH associated with ILD (PH-ILD). The present study aimed to analyze the clinical characteristics of patients with PH-ILD and explore the correlation and predictive value of the easily obtainable indicators with respect to the severity of PH in patients with ILD. The results indicated that the red blood cell distribution width (RDW) and mean platelet volume (MPV) of patients with ILD with the moderate-to-severe PH (Ms-PH) were significantly higher compared with those of patients with ILD without PH and those with Mild-PH (P<
0.05). Age, RDW, MPV and immunoglobulin G levels were emerged as independent risk factors for Ms-PH in patients with ILD. Receiver operating characteristic curve analysis demonstrated that the combination of RDW and MPV enhances the diagnostic efficiency for Ms-PH in patients with ILD. Consequently, the present study demonstrated that RDW and MPV are predictive factors for Ms-PH in patients with ILD.