Multi-Pass Arrival Time Correction in Cyclic Ion Mobility Mass Spectrometry for Imaging and Shotgun Lipidomics.

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Tác giả: Kassaporn Duangkumpha, Jun Xian Goh, Narumol Jariyasopit, Sakda Khoomrung, Martin E Palmer, Yongyut Sirivatanauksorn, Pattipong Wisanpitayakorn

Ngôn ngữ: eng

Ký hiệu phân loại: 577.56 +Urban ecology

Thông tin xuất bản: United States : ACS measurement science au , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 674196

Direct-infusion mass spectrometry (DI-MS) and mass spectrometry imaging (MSI) are powerful techniques for lipidomics research. However, annotating isomeric and isobaric lipids with these methods is challenging due to the absence of chromatographic separation. Recently, cyclic ion mobility mass spectrometry (cIM-MS) has been proposed to overcome this limitation. However, fluctuations in room conditions can affect ion mobility multipass arrival times, potentially reducing annotation confidence. In this study, we developed a multipass arrival time correction method that proved effective across various dates, room temperatures, ion mobility settings, and laboratories using mixtures of reference standards. We observed slight variations in the linear correction lines between lipid and nonlipid molecules, underscoring the importance of choosing appropriate reference molecules. Based on these results, we demonstrated that an accurate multipass arrival time database can be constructed from corrected
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