Mimicking women's endocrine milieu in mice for women's health-related studies.

• Tác giả: Laura Battista, Pierre-Alain Binz, Cathrin Brisken, Stephen J Bruce, Céline Constantin, Csaba László, Daria Matvienko, Valentina Scabia
• Ngôn ngữ: eng
• Ký hiệu phân loại: 796.343 Squash
• Thông tin xuất bản: England : npj women's health , 2025
• Bộ sưu tập: NCBI
• ID: 674211

Tóm tắt

To improve preclinical studies and their translation, patient-derived xenografts (PDXs) are increasingly used. They have human-specific tumor characteristics and reflect intra and inter-tumor heterogeneity. However, the endocrine milieu differs between humans and host mice. In light of sex-specific cancer biology and a rise in endocrine-related cancers there is an urgent need to correctly reflect the hormonal milieu in PDX models. We show that female mice of