BACKGROUND: Transcription factor specificity protein (SP2) regulates various cellular functions, including cell division, proliferation, invasion, metastasis, differentiation, and death
however, its role has not been studied in prominent medical conditions including diabetic encephalopathy (DE). Therefore, this study addressed its physiological function in the context of DE to also better characterize its possible use in the context of predictive, preventive, and personalized medicine (PPPM). METHODS: The anti-inflammatory and anti-DE actions of SP2 were investigated using three animal models (SP2 RESULTS: Mechanistically, SP2-knockout (SP2 CONCLUSIONS: These findings highlight SP2 as key biological targets for DE and reveal the infammation-related potential molecular mechanism of DE, which is helpful for early risk prediction and targeted prevention of DE. In conclusion, our study provides a new perspective for developing a PPPM method for managing DE patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13167-024-00394-0.