Metal-organic frameworks (MOFs) have garnered significant attention in recent years for their potential to revolutionize heat exchanger performance, thanks to their high surface area, tunable porosity, and exceptional adsorption capabilities. This review focuses on the integration of MOFs into heat exchangers to enhance heat transfer efficiency, improve moisture management, and reduce energy consumption in Heating, Ventilation and Air Conditioning (HVAC) and related systems. Recent studies demonstrate that MOF-based coatings can outperform traditional materials like silica gel, achieving superior water adsorption and desorption rates, which is crucial for applications in air conditioning and dehumidification. Innovations in synthesis techniques, such as microwave-assisted and surface functionalization methods, have enabled more cost-effective and scalable production of MOFs, while also enhancing their thermal stability and mechanical strength. However, challenges related to the high costs of MOF synthesis, stability under industrial conditions, and large-scale integration remain significant barriers. Future developments in hybrid nanocomposites and collaborative efforts between academia and industry will be key to advancing the practical adoption of MOFs in heat exchanger technologies. This review aims to provide a comprehensive understanding of current advancements, challenges, and opportunities, with the goal of guiding future research toward more sustainable and efficient thermal management solutions.