Safety of Mechanically Fibrillated Cellulose Nanofibers (CNFs) by Inhalation Exposure Based on TG412.

• Tác giả: Koji Aoki, Satoshi Fujita, Tamotsu Ishizuka, Shuichi Tanoue, Akinori Tokunaga, Yoshihiro Yamashita
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Nanomaterials (Basel, Switzerland) , 2025
• Bộ sưu tập: NCBI
• ID: 67460

Tóm tắt

An investigation into the acute toxicity of mechanically fibrillated cellulose nanofibers (fib-CNFs), with a fiber length ranging from 500 to 600 nm, was conducted in accordance with the OECD TG412 guidelines. In this study, rats were exposed to fib-CNFs via nasal inhalation for 6 h daily over a 28-day period. The highest exposure concentration was set at 35 mg/m