Laparoscopic cholecystectomy (LC) is widely accepted as the gold standard procedure for gallbladder removal. While LC is generally acknowledged for its safety and efficacy, this surgical intervention still carries the risk of complications, including postoperative hemorrhage, alongside other rare causes of bleeding. Postoperative recurrent bleeding often arises from complex underlying causes and demands swift identification and intervention for effective management. Here, we present a rare case of a patient diagnosed with an overlapping syndrome comprising primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), along with Sjögren's syndrome (SS). This patient experienced recurrent massive hemorrhage following cholecystectomy and was ultimately diagnosed with acquired hemophilia A (AHA). We provide a detailed account of the diagnostic and management processes involved.