T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration.

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Tác giả: Yinuo Fan, Lu Feng, Wenhui Hu, Zhaowei Jiang, Gang Li, Haoxin Li, Yashi Li, Sien Lin, Haixing Wang, Xu Yan

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Singapore : Journal of orthopaedic translation , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 675431

UNLABELLED: Last decade has witnessed increasing evidence which highlights the roles of immune cells in bone regeneration. Numerous immune cell types, including macrophages, T cells, and neutrophils are involved in fracture healing by orchestrating a series of events that modulate bone formation and remodeling. In this review, the role of T cell immunity in fracture healing has been summarized, and the modulatory effects of T cell immunity in inflammation, bone formation and remodeling have been highlighted. The review also summarizes the specific roles of different T cell subsets, including CD4 THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: Delayed unions or non-unions of bone fractures remain a challenge in clinical practice. Developing a deep understanding of the roles of immune cells, including T cells, in fracture healing will facilitate the advancement of novel therapeutics of fracture nonunion. This review summarizes the current understanding of different T cell subsets involved in various phases of fracture healing, providing insights for targeting T cells as an alternative strategy to enhance bone regeneration.
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