Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting.

• Tác giả: Yanan Chang, Kui Chen, Lin Feng, Haoyang Hao, Ying Ji, Chan Li, Juan Li, Mengyao Li, Zhicai Liu, Xianwei Luo, Hongyu Tang, Chutian Wang, Zhijie Wang, Gengmei Xing, Jingru Yang, Mingxin Yang, Hui Yuan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: United States : Innovation (Cambridge (Mass.)) , 2025
• Bộ sưu tập: NCBI
• ID: 675471

Tóm tắt

We developed magnetically driven bionic drug-loaded nanorobots (MDNs) to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional (3D) magnetic manipulation platform (MMP) system to precisely control their movement mode. MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles (7.02 ± 0.18 nm). Doxorubicin (12% ± 2% [w/w]) was encapsulated in MDNs by an imide bond. MDNs could imitate the movement mode of a school of wild herrings (e.g., re-dispersion/arrangement/vortex/directional movement) to adapt to the changing and complex physiological environment through the 3D MMP system. MDNs overcame blood flow resistance and biological barriers using optimized magnetic driving properties according to