Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by aseptic, non-infectious skin lesions. This report details a case of PG in a 49-year-old woman with multiple comorbidities and limited access to healthcare resources. In the absence of standardized treatment protocols, the case illustrates the successful application of a multidisciplinary therapeutic approach combining surgical intervention with medical management using corticosteroids and immunomodulators. The report includes visual documentation of the treatment process and disease progression, providing a comprehensive timeline of clinical outcomes. Furthermore, it highlights the challenges of managing PG in resource-constrained settings, emphasizing the importance of consistent monitoring and proactive intervention to prevent complications.