Severe Thrombocytopenia in the Post-surgical Context and Administration of Factor VIIII (FVIII)/von Willebrand Factor (VWF) Concentrate in a Patient With von Willebrand Disease Type 2M.

• Tác giả: Daniela Baptista, Lourenço Castro E Sousa, Rita Pardal, Marta Rebelo, Maria Isabel Simões
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cureus , 2025
• Bộ sưu tập: NCBI
• ID: 675514

Tóm tắt

Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It can be associated with a life-threatening risk of excessive bleeding in surgical procedures, and may require prophylactic treatment with a combined factor VIIII (FVIII)/von Willebrand factor (VWF) concentrate. Management of these patients may be challenging when trying to achieve the balance between avoiding the risk of haemorrhage and causing a risk of thrombosis with the treatment. We present a complex case of severe thrombocytopenia in a post-surgical setting, in which the timeline suggests a direct relationship between the worsening of platelet count and wilate administrations.