Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells.

• Tác giả: Hiroyuki Abe, Natsuki Ishikawa, Hiroteru Kamimura, Kenya Kamimura, Naruhiro Kimura, Yuichirou Maeda, Akira Sakamaki, Shuji Terai, Atsunori Tsuchiya, Yusuke Watanabe, Takeshi Yokoo, Tomoaki Yoshida
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.07995 Diseases
• Thông tin xuất bản: Netherlands : Regenerative therapy , 2025
• Bộ sưu tập: NCBI
• ID: 675526

Tóm tắt

INTRODUCTION: Cirrhosis is a disease with poor prognosis that requires the development of a novel therapeutic approach alternative to liver transplantation. In this study, we focused on the placenta and aimed to clarify the effects of human placental extract (HPE) on cirrhosis. METHODS: A mouse model of carbon tetrachloride-induced cirrhosis was used to evaluate the effect of HPE administration subcutaneously and compared with the control group (n = 8 for each group). In vitro and RESULTS: HPE administration improved serum ALT levels compared to control mice. Furthermore, there was a decrease in the number of senescent cells in the liver and the mRNA levels of secrete senescence-associated secretory phenotype factors CONCLUSIONS: HPE improves serum ALT levels via anti-inflammatory mechanisms in macrophages and senescent cells. HPE serves as a novel agent for cirrhosis treatment.