Metal-organic layer delivers 3-bromopyruvate to mitochondria for metabolic regulation and cancer radio-immunotherapy.

• Tác giả: Wangqing Bian, Tobias Fromme, Xiaomin Jiang, Jinhong Li, Wenbin Lin, Langston Tillman, Chaoyu Wang, Ralph R Weichselbaum, Wenyao Zhen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.8323 Specific therapies and kinds of therapies
• Thông tin xuất bản: England : Chemical science , 2025
• Bộ sưu tập: NCBI
• ID: 675625

Tóm tắt

Abnormal cancer metabolism causes hypoxia and immunosuppression, limiting the anti-tumor efficacy of radiotherapy. Herein, we report a positively charged, mitochondria-targeted nanoscale metal-organic layer conjugated with 3-bromopyruvate (BP), BP/Hf