Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations.

• Tác giả: Nicolas Bertin, James Best, John C Chambers, Ching-Yu Cheng, Calvin Woon Loong Chin, Paul Elliott, Lee Eng Sing, Liuh Ling Goh, Ananya Gupta, Pritesh R Jain, Vinitaa Jha, Chai Jin Fang, Anuradhani Kasturiratne, Prasad Katulanda, Khadija I Khawaja, Woon-Puay Koh, Ishminder K Kooner, Jaspal S Kooner, Jimmy Lee, Khai Pang Leong, Tai Fei Li, Weng Khong Lim, Jian Jin Liu, Marie Loh, Dorrain Low, Theresia Mina, Shi Qi Mok, Hong Kiat Ng, Joanne Ngeow, Su Qin Peh, Elio Riboli, Charumathi Sabanayagam, Nilanjana Sadhu, E-Shyong Tai, Patrick Tan, Darwin Tay, Rob M van Dam, Sim Xueling, Jian-Min Yuan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.959 *Anguinomorphoidea
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 675710

Tóm tắt

 To identify biomarkers and pathways to Type-2 diabetes (T2D), a major global disease, we completed array-based epigenome-wide association in whole blood in 5,709 Asian people. We found 323 Sentinel CpGs (from 314 genetic loci) that predict future T2D. The CpGs reveal coherent, nuclear regulatory disturbances in canonical immune activation pathways, as well as metabolic networks involved in insulin signalling, fatty acid metabolism and lipid transport, which are causally linked to development of T2D. The CpGs have potential clinical utility as biomarkers. An array-based composite Methylation Risk Score (MRS) is predictive for future T2D (RR: 5.2 in Q4 vs Q1
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