Neoadjuvant chemotherapy response and genetic susceptibility in recently parous women with breast cancer.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Sarah DeHorn, Saya Dennis, Michael Gurley, Seema Ahsan Khan, Masha Kocherginsky, Yuan Luo, Andrea Keya Qi, Takahiro Tsukioki, Erica Wrubel

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 675714

 INTRODUCTION: Women with recent parity are at increased short-term breast cancer (BC) risk and face a worse prognosis. The effect of parity on response to neoadjuvant chemotherapy (NAC) is unstudied, and the influence of inherited susceptibility on parity-related short-term risk remains unclear. METHODS: We conducted a retrospective case-cohort study among women aged ≤50 with non-metastatic BC diagnosed between 2010 and 2020 who underwent genetic testing and were treated at Northwestern Medicine. Associations between NAC response and recency of parity were evaluated using multivariate logistic regression, stratified by tumor biologic subtypes. Relationships between germline mutations, recency of parity, and BC were explored via multi-state modeling and linear regression. RESULTS: Among 1,080 eligible women, 231 received NAC. Treatment response was poorer in parous women with triple negative tumors compared to nullipara, regardless of the recency of parity ( CONCLUSION: We observed a poor response to NAC in parous TNBC patients compared to nullipara
  effects of immunotherapy-based regimens deserve evaluation in the context of parity. Post-partum BC occurrence is not increased in
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH