PURPOSE: The present study aimed to examine the clinical distinctions among patients with neuronal surface antibody-associated autoimmune encephalitis (NSAE) diagnosed with anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E), anti-leucine-rich glioma-inactivated 1 encephalitis (LGI1-E), and anti-gamma aminobutyric acid-B receptor encephalitis (GABABR-E), compared with those with viral encephalitis (VE). Additionally, the study aimed to assess the impact of cerebrospinal fluid (CSF) oligoclonal bands (OCBs) on the severity and prognosis of NSAE. PATIENTS AND METHODS: This retrospective analysis included patients with NSAE, encompassing NMDAR-E, LGI1-E, and GABABR-E, alongside individuals with VE. Participants with NSAE were categorized into two groups based on the presence or absence of CSF-specific OCBs. Data regarding demographics, clinical manifestations, magnetic resonance imaging (MRI) findings, CSF analyses and prognosis were collected and analyzed. RESULTS: The findings indicated that younger female with NSAE exhibited a higher incidence of seizure onset, disruption of the blood-CSF barrier (BCSFB), and elevated Q CONCLUSION: In comparison to VE patients, NSAE patients with positive OCBs were more frequently female and exhibited CSF pleocytosis, particularly among those with NMDAR-E. Importantly, the presence of positive OCBs emerged as an independent predictor of unfavorable outcomes in patients with NMDAR-E, LGI1-E, and GABABR-E.