SIL-TAL1-Positive Adult T-ALL with t(11;14)(p15;q11.2): A Rare Case Report Highlighting Prognostic Challenges and Treatment Implications.

• Tác giả: Siyu Chen, Yimei Feng, Nan Li, Shuiqing Liu, Xiangui Peng, Xing Qiang, Yongjie Tang, Shengwang Wu, Cheng Zhang, Xi Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: New Zealand : Journal of inflammation research , 2025
• Bộ sưu tập: NCBI
• ID: 675802

Tóm tắt

 T-cell acute lymphoblastic leukemia (T-ALL) with coexisting SIL-TAL1 fusion and t(11
 14)(p15
 q11.2) is exceedingly rare. There are limited data on the clinical course and outcomes of such patients. We report a case of a 19-year-old male presenting with aggressive T-ALL harboring these abnormalities, along with NOTCH1 and PTEN mutations. SIL-TAL1 positivity is associated with poor prognosis in T-ALL. Despite achieving remission with intensive chemotherapy, the patient experienced rapid relapse and poor overall survival, reflecting the ineffectiveness of conventional treatments. The findings highlight the synergistic role of SIL-TAL1 and t(11
 14) in disease progression and underscore the urgent need for targeted therapies and immunotherapies to improve outcomes in such high-risk cases.