FBXW7 Directly Ubiquitinates and Degrades CTNNB1 Mediating the Suppression of ENKUR in Endometrial Cancer.

• Tác giả: WeiYi Fang, Bin Gong, QiRun Guo, SuiQun Guo, RenTao Hou, Li Lin, Xinhui Liu, YaHui Liu, LuYun Shu, Yao Tang, Qian Wang, XiuQiong Wu, Weiwei Yan, ChunYan Yang, BeiXian Zhou, Ying Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.59012 *Greece
• Thông tin xuất bản: Australia : International journal of biological sciences , 2025
• Bộ sưu tập: NCBI
• ID: 675856

Tóm tắt

Enkurin (ENKUR) is a tumor suppressor in some malignancies. However, its role in endometrial cancer (EC) remains unknown. Here, we firstly observed that reduced ENKUR expression promotes progression and poor prognosis in EC. Moreover,the overexpression of ENKUR suppressed the proliferation, migration, invasion, and intrahepatic dissemination of EC