Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis.

• Tác giả: Rui Chu, Ruhong Fang, Hui Ge, Paipai Guo, Dafei Han, Yongsheng Han, Shufang He, Rui Li, Yang Ma, Hanfei Sun, Jiajie Tu, Qingtong Wang, Wei Wei, Renhao Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 619 Experimental medicine
• Thông tin xuất bản: Australia : International journal of biological sciences , 2025
• Bộ sưu tập: NCBI
• ID: 675862

Tóm tắt

PDE4D has been reported to exhibit significantly elevated levels in the synovium of RA patients compared with OA, yet its role in RA remains underexplored. This study aimed to elucidate the role of the GRK2-PDE4D axis in FLSs and explore its potential as a therapeutic target for RA. Abundant expression of both PDE4D and GRK2 was observed in synovial tissues from both experimental arthritis animals and RA patients, with synchronized expression noted in RA patients. Global deletion of