High-dose Ascorbate Exhibits Anti-proliferative and Anti-invasive Effects Dependent on PTEN/AKT/mTOR Pathway in Endometrial Cancer

• Tác giả: Victoria L Bae-Jump, Shuning Chen, Boer Deng, Jennifer Haag, Catherine John, Weimin Kong, Angeles Alvarez Secord, Xiaochang Shen, Nikita Sinha, Wenchuan Sun, Jiandong Wang, Haomeng Zhang, Chunxiao Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.716 Anti-arrhythmia agents
• Thông tin xuất bản: Australia : International journal of biological sciences , 2025
• Bộ sưu tập: NCBI
• ID: 675865

Tóm tắt

Endometrial cancer (EC) is the most common gynecological malignancy, frequently characterized by PTEN deletion, activation of the AKT/mTOR pathway, and limited effective treatment options for recurrent and advanced patients. High-dose ascorbate or combined with other chemotherapeutic agents shows potent antitumor effects