Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC.

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Tác giả: Ling Li, Shichao Li, Jilin Peng, Le Wang, Yixu Wang, Fanglei Ye, Sijie Yuan, Ziyu Zhai, Yuan Zhang, Yulin Zhang, Kun Zhao

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Frontiers in oncology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 675906

 BACKGROUND: N6-methyladenosine (m6A) RNA modification is crucial for tumor development and progression
  however, which m6A regulators play a pivotal role in head and neck squamous cell carcinoma (HNSCC) remains ambiguous. METHODS: Utilizing the Cancer Genome Atlas (TCGA) database, the expression levels of m6A regulators in HNSCC were examined, which led to the identification of heterogeneous nuclear ribonucleoprotein C ( RESULTS: A reliable survival risk model of m6A was constructed based on the TCGA database. Gene Expression Omnibus (GEO), normal and tumor tissue microarrays (TMA), and tumor tissue samples from patients with HNSCC were observed that a high level of
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