Serum adropin levels as a potential biomarker for predicting diabetic kidney disease progression.

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Tác giả: I-Wen Chen, Szu-Tah Chen, Cheng-Wei Lin, Chia-Ni Lin

Ngôn ngữ: eng

Ký hiệu phân loại: 305.568 +Alienated and excluded classes

Thông tin xuất bản: Switzerland : Frontiers in endocrinology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 675931

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BACKGROUND: To investigate the value of serum adropin in predicting chronic kidney disease (CKD) progression in subjects with type 2 diabetes (T2D). MATERIALS AND METHODS: Serum adropin levels were measured in normal control and T2D patients with various stage of CKD. CKD progression was defined as ≥ 30% decline from the baseline estimated glomerular filtration rate. Logistic regression analysis was applied to assess the association between adropin levels and CKD progression. RESULTS: The study included 58 subjects with T2D (18 early CKD and 40 advanced CKD) and 9 subjects without diabetes (control). Subjects with T2D had significantly higher adropin levels than controls (6393.10 ± 1611.84 vs. 3470.30 ± 1284.41 pg/ml
CONCLUSIONS: The above findings suggest that serum adropin could be applied as a potential biomarker for predicting CKD progression in subjects with T2D. Further research is needed to validate these results and explore the underlying mechanisms.

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