Poor sleep has been associated with diseases including cardiovascular, obesity and mental disorders. However, there is limited information on the correlation between sleep duration and quality with peptic ulcer disease (PUD). This study aimed to investigate the impact of sleep duration and quality on the incidence of PUD in a large Taiwanese population follow-up study. The study participants were recruited from the Taiwan Biobank. Sleep duration, sleep quality, and the presence of PUD were assessed using self-reported questionnaires. The participants were categorized into three groups based on sleep duration: <
7 hours/day, 7 hours/day, and >
7 hours/day. Sleep quality was divided into five levels: very poor, poor, normal, good and very good. The association between sleep duration and quality with incident PUD was analyzed using multiple logistic regression after controlling for confounders. We collected data from 22,561 participants (excluding those with pre-existing PUD, missing basic information, or lacking sleep data). Over an average follow-up period of 43 months, multivariable analysis showed that sleep duration >
7 hours/day (