Electromagnetic transduction therapy (EMTT) is a non-invasive magnetic therapy with high oscillating electromagnetic field power. This pilot randomised controlled trial (ChiCTR1900021031) evaluated EMTT's potential efficacy in relieving pain and other non-symptomatic aspects of chronic myofascial pain (CMP). Forty patients with moderate-to-severe CMP were randomised into treatment (real-EMTT) or control (sham-EMTT) group, and received eight sessions of 20-minute real or sham EMTT over four weeks. Generalised estimating equation was used to estimate changes in outcomes, including Numerical Rating Scale (NRS), Brief Pain Inventory Interference Scale (BPI-IS), Beck Depression Inventory (BDI), and Patient Global Impression of Change scale (PGIC) before and up to 6 months after treatment. Recruitment and compliance rates (95% confidence interval) were 39.6% (30.0%-49.8%) and 87.5% (73.2%-95.8%), respectively. There were no significant changes in NRS, BPI-IS and BDI over time (group*time