The development of an integrated biomimetic membrane capable of rejecting both dyes and salts in a single step, while sustaining stable water permeation, presents a promising solution for textile wastewater treatment. Herein, we report a novel integrated biomimetic membrane integrating an I-quartet artificial water channel (AWC) with sulfonic acid-modified polyamide (PA-SO₃H), which can stably reject both dyes and inorganic salts. The I-quartet channels (2.68 Å), formed via self-assembly of alkyl-ureido-ethyl-imidazole (HC8) molecules, facilitate selective water transport and rejection of both dyes and inorganic salts. Concurrently, the sulfonic acid groups (-SO₃H) could grab water molecules, forming dynamic short hydrogen-bonding network (O-H···O). These hydrogen bonds not only serve as jumping force, lowering the energy barrier for water transport through the alternating hydrophilic-hydrophobic matrix, but also act as an effective antifouling barrier, significantly reducing membrane fouling. The optimal HC83.0-PA-SO₃H membrane exhibits a water permeance of 13.4 L m-2 h-1 MPa-1, approximately 2.7-fold higher than that of the pristine PA membrane, and both high dyes and salts rejection efficiency. Moreover, the membrane sustains stable antifouling characteristics throughout a 19-day endurance test. This innovative membrane design provides a promising solution for the efficient separation of both dyes and inorganic salts in textile wastewater treatment.