Anejaculation (AE) has long been a challenging issue in andrology due to its low clinical reporting rate, leading to an insufficient understanding within the academic community. This case report discusses a 52-year-old AE patient with a long-term history of diabetes mellitus. His seminal vesicles ultrasound images revealed a notable absence of anechoic polycyclic areas, a characteristic not previously reported in AE patients. We hypothesize that this finding is attributable to diabetes-induced seminal vesicles secretory dysfunction, leading to AE in this patient. This case underscores the importance of anechoic polycyclic areas in the physiology of ejaculation and highlights the necessity for further research into the correlation between these areas and various types of ejaculatory disorders, aiming to provide valuable insights for the medical community.