(p)ppGpp and DksA play a crucial role in reducing the efficacy of β-lactam antibiotics by modulating bacterial membrane permeability.

• Tác giả: Prabhakar Babele, Rupak K Bhadra, Meenal Chawla, Bhabatosh Das, Yashwant Kumar, Shashi Kumari, Tushar Matta, Tarosi Senapati, Jyoti Verma
• Ngôn ngữ: eng
• Ký hiệu phân loại: 612.01576 Human physiology
• Thông tin xuất bản: United States : Microbiology spectrum , 2025
• Bộ sưu tập: NCBI
• ID: 676299

Tóm tắt

The key signaling molecules in the bacterial stress-sensing pathway, the alarmone (p)ppGpp and the transcription factor DksA, play a crucial role in bacterial survival during nutritional deprivation and exposure to xenobiotics by modulating cellular metabolic pathways. In