Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions.

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Tác giả: Zhijian Chen, Jinjing Jia, Tongyan Jin, Li Li, Xianying Li, Yun Liu, Xingyi Lv, Min Wang, Chenyi Yang, Yu Yang

Ngôn ngữ: eng

Ký hiệu phân loại: 393.2 Cremation

Thông tin xuất bản: England : Journal of enzyme inhibition and medicinal chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 676347

Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing loss (SNHL) being a major concern. Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention and regeneration strategies. Ferroptosis, a distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due to its potential role in cancer, ageing, and neuronal degeneration, especially hearing loss. The emerging role of ferroptosis as a crucial mediator in SNHL suggests that it may offer a novel therapeutic target for otoprotection. This review aims to summarise the intricate connection between ferroptosis and SNHL, offering a fresh perspective for exploring targeted therapeutic strategies that could potentially mitigate cochlear cells damage and enhance the quality of life for individuals with hearing impairments.
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