Superhydrophilic Nanostructured Microparticles for Enhanced Phosphoprotein Enrichment from Alzheimer's Disease Brain.

• Tác giả: Cheng Chen, Yifan Chen, Yun Cui, Xuefang Dong, Xiuling Li, Xinmiao Liang, Danyi Shang, Yongyang Song, Shutao Wang, Feifei Xu, Congcong Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.317 *Conversion and maintenance
• Thông tin xuất bản: United States : ACS nano , 2025
• Bộ sưu tập: NCBI
• ID: 676366

Tóm tắt

Alzheimer's disease (AD) is an incurable neurodegenerative disorder and closely related to abnormal phosphoproteoforms. The analysis of low-abundance phosphoproteoforms relies heavily on the enrichment of phosphoproteins. However, existing phosphoprotein enrichment materials suffer from either low selectivity or low coverage due to the unavoidable unspecific adsorption of background proteins. Here, we propose a strategy of nanostructure-enabled superhydrophilic surfaces and synthesize Ti