Adaptation to changes in environmental availability of nutrients such as amino acids is crucial for cellular survival. Given the requirement of amino acids as building blocks for proteins and their capacity to induce activation of the mTORC1 pathway, which plays a vital role in regulating protein synthesis and cell growth, amino acid sensing in mammalian cells is understandably critical for cellular maintenance, growth, and proliferation. Members of the System A amino acid (AA) transporter family play an important role in mediating the sodium (Na