Splicing factor RBM10 loss fuels thyroid cancer metastasis.

• Tác giả: Kevin Coughlin, Ledong Wan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 665.779 Production of manufactured gases by mixing fuel gases from several sources
• Thông tin xuất bản: United States : The Journal of experimental medicine , 2025
• Bộ sưu tập: NCBI
• ID: 676791

Tóm tắt

In this issue of JEM, Krishnamoorthy et al. (https://doi.org/10.1084/jem.20241029) identify the loss of the splicing factor RBM10 as a driver of metastasis in thyroid cancer through the regulation of RNA splicing. The synthetic lethal interaction between NF-κB and RBM10 loss reveals a potential therapeutic vulnerability.