The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling.

• Tác giả: Andréa B Ball, Nicholas A Bayley, Steven J Bensinger, Amber R Bianchi, Carolina Chavez, Angel A Cortez, Ajit S Divakaruni, Thomas G Graeber, Alexander Hoffmann, Wei Yuan Hsieh, Neira Ibrahimovic, Anthony E Jones, Amy Rios, Alessandro Sammarco
• Ngôn ngữ: eng
• Ký hiệu phân loại: 371.04 Alternative schools
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 676922

Tóm tắt

Metabolites and metabolic co-factors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofactor Coenzyme A (CoA) enhances IL-4 driven alternative macrophage activation [m(IL-4)]