Astragalin Exerted Hypoglycemic Effect by Both Inhibiting α-Glucosidase and Modulating AMPK Signaling Pathway.

• Tác giả: Qian Li, Fan Liu, Huijie Lu, Zhangchang Yang, Donglai Zhou, Yuxiao Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 344.095 Science and technology both formerly also 341.7675
• Thông tin xuất bản: Switzerland : Nutrients , 2025
• Bộ sưu tập: NCBI
• ID: 67706

Tóm tắt

BACKGROUND: The hypoglycemic activity of mulberry leaf polyphenols has been widely studied, while its mechanism of action needs further elucidation. METHODS: The inhibitory activity mechanism of astragalin on α-glucosidase was investigated with a combination of multispectroscopic techniques and molecular docking. The hypoglycemic pathway was further revealed with a high-glucose human hepatocellular carcinomas (HepG2) cell model. RESULTS: The results indicated that astragalin inhibited α-glucosidase with IC CONCLUSIONS: This study provides new insights into the potential utilization of astragalin-rich foods in the improvement of diabetes mellitus.