HMGA1 Regulates IRS2 to Promote Inflammatory Responses and Oxidative Stress Injury in MPP

• Tác giả: Wenhui Fan, Bing Fu, Hongxia Nie, Dongxun Xu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 181.4 *India
• Thông tin xuất bản: United States : Cell biochemistry and biophysics , 2025
• Bộ sưu tập: NCBI
• ID: 677218

Tóm tắt

Parkinson's disease (PD) is a prevalent neurodegenerative disorder for which novel treatment approaches are continuously sought. This study investigates the role of high-mobility group A1 (HMGA1) in modulating inflammatory responses and oxidative stress injury in PD. We utilized the murine dopaminergic neuronal cell line MN9D, treating cells with 1-methyl-4-phenylpyridinium ion (MPP