A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis.

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Tác giả: Christine A Denny, Alessandra Franceschini, Michelle Jin, Marcos Lanio, Simon O Ogundare, Sofia Leal Santos, Sophia Sorid, Alicia R Whye

Ngôn ngữ: eng

Ký hiệu phân loại: 727.9 Other buildings for educational and research purposes

Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 677282

In the last decade, activity-dependent strategies for labelling multiple immediate early gene (IEG) ensembles in mice have generated unprecedented insight into the mechanisms of memory encoding, storage, and retrieval. However, few strategies exist for brain-wide mapping of multiple ensembles, including their overlapping population, and none incorporate capabilities for downstream network analysis. Here, we introduce a scalable workflow to analyze traditionally coronally-sectioned datasets produced by activity-dependent tagging systems. Intrinsic to this pipeline is
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