Long-term risk of mortality and loss to follow-up in children and adolescents on antiretroviral therapy in Asia.

• Tác giả: Anggraini Alam, Kulkanya Chokephaibulkit, Quy Tuan Du, Siew Fong, Azar Kariminia, Vohith Khol, Aarti Kinikar, Pope Kosalaraks, Nagalingeswaran Kumarasamy, Vidya Mave, Thahira Mohamed, Dina Muktiarti, Revathy Nallusamy, Dinh Qui Nguyen, Lam Nguyen, Smita Nimkar, Pradthana Ounchanum, Thanyawee Puthanakit, Annette Sohn, Tavitiya Sudjaritruk, Tulathip Suwanlerk, Dewi Wati, Nik Khairulddin Nik Yusoff
• Ngôn ngữ: eng
• Ký hiệu phân loại: 915 Geography of and travel in Asia
• Thông tin xuất bản: England : HIV medicine , 2025
• Bộ sưu tập: NCBI
• ID: 677447

Tóm tắt

 OBJECTIVE: We described mortality and loss to follow-up (LTFU) in children and adolescents who were under care for more than 5 years following initiation of antiretroviral therapy (ART). METHODS: Patients were followed from 5 years after ART until the earlier of their 25th birthday, last visit, death, or LTFU. We used Cox regression to assess predictors of mortality and competing risk regression to assess factors associated with LTFU. RESULTS: In total, 4488 children and adolescents initiating ART between 1997 and 2016 were included in the analysis, with a median follow-up time of 5.2 years. Of these, 107 (2.2%) died and 271 (6.0%) were LTFU. Mortality rate was 4.35 and LTFU rate 11.01 per 1000 person-years. Increased mortality was associated with AIDS diagnosis (adjusted hazard ratio [aHR] 1.71
  95% confidence interval [CI] 1.24-2.37), current CD4 count <
 350 cells/mm CONCLUSION: For children and adolescents surviving 5 years on ART, both current CD4 and viral load remained strong indicators that help to keep track of their treatment outcomes. More effort should be made to monitor patients who switch treatments.