Machiavellianism is a personality trait that denotes cunning, manipulative ability, and a desire to gain power by any possible means. Machiavellianism is a subclinical form of psychopathy that has an impact on individual health, professional settings and social order. Machiavellians are more at risk of developing anxiety and depression
however, the underpinning mechanism has not been studied clearly. To avoid major mental health illnesses, it is critical to understand the psychological reasons, brain areas involved, and biochemical substrates for the development of Machiavellianism. This review will address the psychological, clinical and neural correlations of Machiavellianism, its impact on society, and highlight loopholes in comprehending the development of Machiavellianism.