Identification of targetable epigenetic vulnerabilities for uveal melanoma.

• Tác giả: E V Adis, D C Bilbao, S Borges, S Braun, S P Brothers, Z M Correa, J J Dollar, J W Harbour, E Karaca, S Kurtenbach, J N Kutsnetsoff, S Lopez, G I Quintana, S Rodriguez, V Stathias, C H Volmar, G Yenisehirli, A N Zuniga
• Ngôn ngữ: eng
• Ký hiệu phân loại: 946.7 *Eastern Spain and Andorra
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 677664

Tóm tắt

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a strong predilection for hepatic metastasis, occurring in approximately 50% of cases. Metastatic UM remains highly resistant to therapy and is almost invariably fatal. The strongest genetic drivers of UM metastasis are loss-of-function mutations in tumor suppressor