BACKGROUND: Higher greenspace exposure has been associated with lower risk of certain cancers. However, few studies have evaluated potential benefits of increasing population-level exposure to greenspace on cancer disparities. We estimated the impact of a hypothetical intervention to increase residential greenspace cover on neighborhood socioeconomic disparities in total, breast, colorectal, lung, and prostate cancer incidence. METHODS: Our study included 411,787 cancer-free UK Biobank participants. Percentage of greenspace around baseline residential addresses (300m, 1000m distance buffers) was derived by combining domestic gardens and greenspace cover from the Generalized Land Use Database. We categorized neighborhood socioeconomic deprivation using the Index of Multiple Deprivation (2010). We estimated hazard ratios (HR) and 95% confidence intervals (CI) of each cancer associated with greenspace, adjusting for sociodemographic and lifestyle factors. We additionally adjusted for air pollution in supplementary analyses as we a-priori hypothesized that it was on the causal pathway between greenspace and cancer. Further, we used parametric g-computation to calculate the standardized 10-year risk of each cancer, comparing the least to most socioeconomically disadvantaged participants, both without any hypothetical greenspace intervention and under a hypothetical intervention to increase residential greenspace cover to a favorable threshold (75th percentile amongst the least socioeconomically deprived participants). RESULTS: We documented 40,519 incident cases of cancer over 4,210,008 person-years follow-up. An interquartile range increase in greenspace cover within 300m was associated with lower incidence of total (HR 0.98
95% CI 0.97, 1.00) and lung (HR 0.96
95% CI 0.92, 0.99) cancer, and was suggestively associated with lower prostate and breast cancer incidence, but not colorectal cancer. Additional adjustment for fine particulate matter air pollution (PM DISCUSSION: Higher residential greenspace cover was associated with lower total and lung cancer incidence, and suggestively associated with lower breast and prostate cancer incidence. Policies to increase residential greenspace cover may reduce the risk of certain cancers, particularly among socioeconomically disadvantaged groups.