The effect of Plasmodium falciparum exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01

• Tác giả: Selidji Todagbe Agnandji, Joseph J Campo, Claudia Daubenberger, Carlota Dobaño, David Dosoo, Chenjerai Jairoce, Simon Kariuki, Kwadwo Asamoah Kusi, Dídac Macià, Luis M Molinos-Albert, Gemma Moncunill, Benjamin Mordmüller, Maximilian Mpina, Hermann Sorgho
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: United States : The Lancet. Infectious diseases , 2025
• Bộ sưu tập: NCBI
• ID: 677766

Tóm tắt

 BACKGROUND: The RTS,S/AS01 METHODS: In this observational study, we included children and infants from six African countries (Burkina Faso, Gabon, Ghana, Kenya, Mozambique, and Tanzania) enrolled in the MAL067 immunology ancillary study of the RTS,S/AS01 FINDINGS: We included 718 comparator-vaccinated infants (348 [48%]) and children (370 [52%]) and 606 RTS,S/AS01 INTERPRETATION: Interference between passive immunity and vaccine response is clinically significant and might affect the implementation of next-generation CSP-based vaccines for young infants and mothers as well as passive immunisation with human monoclonal antibodies. FUNDING: US National Institutes of Health, National Institute of Allergy and Infectious Diseases
  PATH-Malaria Vaccine Initiative
  Spanish Ministerio de Economía y Competitividad (Instituto de Salud Carlos III), European Regional Development Fund and European Social Fund
  Fundación Ramón Areces
  Spanish Ministry of Science and Innovation
  and Generalitat de Catalunya (CERCA Program).