An increase in reactive oxygen species underlies neonatal cerebellum repair.

• Tác giả: N Sumru Bayin, Jens Bager Christensen, Salsabiel El Nagar, Alexandra L Joyner, Richard Koche, Anna Pakula, Adam James Reid, Daniel N Stephen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 665.823 Oxygen
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 677806

Tóm tắt

The neonatal mouse cerebellum shows remarkable regenerative potential upon injury at birth, wherein a subset of Nestin-expressing progenitors (NEPs) undergoes adaptive reprogramming to replenish granule cell progenitors that die. Here, we investigate how the microenvironment of the injured cerebellum changes upon injury and contributes to the regenerative potential of normally gliogenic