Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease.

• Tác giả: Steven E Arnold, J Alex Becker, Joyita Dutta, Bernard J Hanseeuw, Heidi I L Jacobs, Keith A Johnson, Elouise A Koops, Julie C Price, Prokopis C Prokopiou, Reisa A Sperling, Maxime Van Egroo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.831 *Alzheimer disease
• Thông tin xuất bản: United States : Alzheimer's & dementia : the journal of the Alzheimer's Association , 2025
• Bộ sưu tập: NCBI
• ID: 677874

Tóm tắt

INTRODUCTION: Alterations in locus coeruleus' (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown. METHODS: We examined associations of [ RESULTS: FDG-PET-derived LC metabolism was elevated in the earliest preclinical stages and lower in later disease stages. Higher LC metabolism was associated with attenuated memory decline in preclinical stages, particularly in those with low CSF Aβ DISCUSSION: Higher locus coeruleus [ HIGHLIGHTS: LC FDG-PET signal is lower in Alzheimer's disease (AD) patients. LC FDG-PET signal is higher in the preclinical stage of AD. We observed less memory decline in those with higher LC FDG-PET signal. Higher LC FDG-PET signal conferred cognitive resilience in preclinical AD.